The Lie to Me TV series was inspired by the work of Dr. Paul Ekman and his reputation as the world best lie catcher. Dr. Ekman played a key role in the production of the show and consulted the writers and actors on how best to portray the science of non-verbal behavior and deception. This resulted in much of what you see on Lie to Me (particularly in Season’s 1 and 2) being heavily rooted in science.
However, the show was meant for entertainment first, science second. Therefore to correct any of the creative freedom exercised by the writers, Dr. Ekman kept an episode by episode Blog where he would differentiate the facts from the myths.
You can find these Blog’s here